Hybridoma Development
Rabbits are a gold standard host for polyclonal antibody production, consistently generating high‑affinity antibodies with broad epitope recognition.
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Bovine Ultra-Long CDR3 Antibodies
Custom bovine ultra-long CDR3 antibody development services designed for research, diagnostic, and therapeutic applications. Our bovine antibody platform supports the discovery of highly specific antibodies capable of recognizing unique epitopes and challenging targets.
MONOCLONAL ANTIBODY SERVICE
Overview
LAMPIRE’s Bovine Ultra-Long CDR3 Antibody platform enables discovery of uniquely structured binding domains through single B cell sorting and directed sequencing of ultra-long CDR3 regions found only in bovine antibodies. These compact, disulfide stabilized knob domains are supported by flexible stalk regions, enabling precise engagement of complex antigen surfaces and access to epitopes often unreachable with conventional antibody formats.
Bovine ultra-long CDR3 antibodies are exceptionally small, typically three to five kilodaltons, yet highly stable and well defined. Direct sequence recovery preserves bovine immune diversity while eliminating library bias. All sequences are delivered with full client IP ownership, and antibody derived candidates can be engineered into advanced recombinant formats, including knobbody and bispecific designs.
Complimentary Antigen Design and Protocol Review
Take advantage of our complimentary Antigen Design and Protocol Review to optimize your custom antibody development strategy. Our scientific experts provide tailored solutions for difficult targets, antibody production, downstream testing, and specialized laboratory services, delivering the technical expertise needed to maximize project success.
Unique Species
1
Animals on US Farms
6000
Vivariums
10
Custom Projects Annually
800
Why Choose Us?
Access to a rare and highly differentiated bovine antibody repertoire
Sequence forward discovery without library generation or panning bias
Experience translating novel binding domains into advanced recombinant formats
Direct sequence recovery with full transparency and client owned IP
US based, AAALAC accredited facilities with quality oversight
Capabilities
- Bovine immunization using diverse antigen formats including proteins, cells, peptides, DNA, mRNA LNPs, and VLPs
- Single B cell sorting to isolate antigen specific B cells
- Directed sequencing and NGS based recovery of ultralong CDR3 domains
- Recombinant expression options with optional purified antibody delivery
- Optional screening including ELISA, cell based binding, kinetics, and epitope binning
Benefits
- Expanded Epitope Access: Ultralong CDR3 knob domains enable engagement of complex or recessed antigen surfaces that are often inaccessible to conventional antibody formats.
- Compact Domains with Engineering Flexibility: Picobodies are exceptionally small yet stable, supporting flexible engineering into advanced recombinant formats such as knobbody and bispecific designs.
- Sequence Confident Selection Optional binding and characterization workflows support early evaluation of specificity and differentiation to guide downstream decisions.orward Transparency: Direct recovery of paired VH and VK sequences provides full visibility and long term value through client owned IP.
- Transparency and Control Direct sequence recovery with full client IP ownership ensures clear handoff into engineering and development.
Resource Center
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